The value of cold storage whole blood platelets in trauma resuscitation is like real estate: a function of ‘location, location, location’

The real estate of NOS signaling: location, location, location.

While sympathetic stimulation of the heart produces chronotropic, inotropic, and lusitropic effects, increased frequency alone causes a positive forcefrequency relationship (FFR) and frequency-dependent acceleration of relaxation (FDAR).1 That is, contraction amplitude and relaxation rate are increased with increasing frequency in most species (including humans). The key mechanism involved in t...

The real estate of cardiac signaling: location, location, location.

D etermining how cells distinguish between adaptive and maladaptive signals when they appear to share the same molecular pathways has been a vexing biological problem. The ability to identify distinctive features of a pathophysiological response compared with a physiological response would allow for the rational design of approaches to eliminate or diminish undesirable consequences of pathophys...

The Real Estate of Small Bowel Lesions During Capsule Endoscopy; Location, Location, Location

The capsule endoscopic localization study by Scott et al.1 in this current issue of VHJOE has once again emphasized the propensity of small bowel vascular lesions, thought to be involved in obscure gastrointestinal bleeding, to congregate within the proximal landscape of the midgut. The principal aim of the study was to examine the distribution of lesions found during capsule endoscopy within t...

Taking Location Seriously: Is Location a Function or a Relation?

The focus of the paper is ‘location as a function’ vs ‘location as a relation’. To this end, I develop as a logical theory a high-level description of a data model with two embedding spaces, one Euclidean and one topological, and then show how by using a ‘mirroring’ relation the structure that a spatial object takes in one embedding space constrains the structure it can take in the other. In co...

Location, Location, Location: The Impact of Guideline Grid Location on the Value of Sentencing Enhancements Given By Judges in Maryland